Sesquiterpene Coumarins from <i>Ferula fukanensis</i> and Their Pro-inflammatory Cytokine Gene Expression Inhibitory Effects

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Sesquiterpene coumarins from Ferula fukanensis and their pro-inflammatory cytokine gene expression inhibitory effects.

Six new sesquiterpene coumarin derivatives, fukanefuromarin H-M (1-6), were isolated from an 80% aqueous methanol extract of the roots of Ferula fukanensis. The structures were elucidated on the basis of spectroscopic evidence, particularly heteronuclear multiple-bond connectivity (HMBC) and high-resolution MS. The sesquiterpene coumarin derivatives inhibited nitric oxide (NO) and inducible NO ...

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ژورنال

عنوان ژورنال: Chemical and Pharmaceutical Bulletin

سال: 2013

ISSN: 0009-2363,1347-5223

DOI: 10.1248/cpb.c12-01028